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Image Search Results


Immunohistochemical findings of the upper lip mucosal lesion. (A) CD3 immunostaining. (B) CD8α immunostaining using the rat monoclonal antibody clone F3-B2. More than 90% of the neoplastic lymphocytes were positive for both CD3 and CD8α.

Journal: Frontiers in Veterinary Science

Article Title: Bleomycin-based electrochemotherapy for recurrent oral CD8-positive epitheliotropic T-cell lymphoma in a dog with durable local control and necrotic regional lymph node changes: a case report

doi: 10.3389/fvets.2026.1942467

Figure Lengend Snippet: Immunohistochemical findings of the upper lip mucosal lesion. (A) CD3 immunostaining. (B) CD8α immunostaining using the rat monoclonal antibody clone F3-B2. More than 90% of the neoplastic lymphocytes were positive for both CD3 and CD8α.

Article Snippet: CD3 immunohistochemistry was performed using a rat anti-human CD3 monoclonal antibody (clone CD3-12; Bio-Rad), which is cross-reactive with canine CD3.

Techniques: Immunohistochemical staining, Immunostaining

Histopathological findings of the excised left mandibular lymph node. Hematoxylin and eosin (HE) stain. (A) Low-power view showing extensive necrosis replacing most of the normal lymph node architecture. Scale bar = 1 mm. (B) High-power view of the necrotic area. Scale bar = 50 μm. (C) Small residual aggregate of lymphoid cells identified within the excised lymph node. Scale bar = 50 μm. (D) CD3 immunostaining. Although the residual lymphoid cells were CD3-positive, extensive necrosis precluded definitive determination of lymphomatous involvement. Scale bar = 50 μm.

Journal: Frontiers in Veterinary Science

Article Title: Bleomycin-based electrochemotherapy for recurrent oral CD8-positive epitheliotropic T-cell lymphoma in a dog with durable local control and necrotic regional lymph node changes: a case report

doi: 10.3389/fvets.2026.1942467

Figure Lengend Snippet: Histopathological findings of the excised left mandibular lymph node. Hematoxylin and eosin (HE) stain. (A) Low-power view showing extensive necrosis replacing most of the normal lymph node architecture. Scale bar = 1 mm. (B) High-power view of the necrotic area. Scale bar = 50 μm. (C) Small residual aggregate of lymphoid cells identified within the excised lymph node. Scale bar = 50 μm. (D) CD3 immunostaining. Although the residual lymphoid cells were CD3-positive, extensive necrosis precluded definitive determination of lymphomatous involvement. Scale bar = 50 μm.

Article Snippet: CD3 immunohistochemistry was performed using a rat anti-human CD3 monoclonal antibody (clone CD3-12; Bio-Rad), which is cross-reactive with canine CD3.

Techniques: H&E Stain, Immunostaining